IL-5-directed approaches in the treatment of eosinophil-driven diseaselate
نویسندگان
چکیده
Eosinophils are involved in the initiation and propagation of diverse inflammatory responses, including antigen presentation and the release of proinflammatory cytokines, chemokines, lipid mediators and cytotoxic granules (1-4) (Fig. 1). Tissue damage and dysfunction resulting from secretion of these pleiotropic mediators is a common pathogenic component in several diseases, including atopic asthma (5), eosinophilic bronchitis (6), nasal polyposis (7), atopic dermatitis (8, 9), eosinophil-associated gastrointestinal disorders (10) (eosinophilic esophagitis [EE], eosinophilic gastroenteritis) and hypereosinophilic syndromes (HES) (11).
منابع مشابه
Asthma Endotypes and an Overview of Targeted Therapy for Asthma
Guidelines for the management of severe asthma do not emphasize the measurement of the inflammatory component of airway disease to indicate appropriate treatments or to monitor response to treatment. Inflammation is a central component of asthma and contributes to symptoms, physiological, and structural abnormalities. It can be assessed by a number of endotyping strategies based on "omics" tech...
متن کاملMonoclonal Antibody-based Therapy for Eosinophilic Oesophagitis
Eosinophilic oesophagitis is an inflammatory condition associated with marked eosinophil accumulation in the mucosal tissues of the oesophagus. Eosinophils are major pro-inflammatory cells thought to make a significant contribution to allergic diseases that affect the upper and lower airways, skin, and gastrointestinal tract. Type 2 cytokines such as interleukin (IL)-5 and IL-13 are central to ...
متن کاملInterleukin-9 enhances interleukin-5 receptor expression, differentiation, and survival of human eosinophils.
Interleukin-9 (IL-9) has been implicated in the pathogenesis of allergic disorders. To examine the interaction between IL-9 and eosinophils, we evaluated mature peripheral blood eosinophils for their expression of the specific alpha-subunit of the IL-9 receptor (IL-9R-alpha). The expression of IL-9R-alpha by human eosinophils was detected at the messenger RNA (mRNA) and protein levels by revers...
متن کاملIMMUNOBIOLOGY Interleukin-9 enhances interleukin-5 receptor expression, differentiation, and survival of human eosinophils
Interleukin-9 (IL-9) has been implicated in the pathogenesis of allergic disorders. To examine the interaction between IL-9 and eosinophils, we evaluated mature peripheral blood eosinophils for their expression of the specific a-subunit of the IL-9 receptor (IL-9R–a). The expression of IL-9R–a by human eosinophils was detected at the messenger RNA (mRNA) and protein levels by reverse transcript...
متن کاملInterleukin 5 regulates the isoform expression of its own receptor alpha-subunit.
The receptor for interleukin 5 (IL-5) consists of a cytokine-specific alpha chain (IL-5Ralpha) and a signaling beta chain, which is shared with interleukin 3 (IL-3) and granulocyte-macrophage colony-stimulating factor (GM-CSF). These 3 cytokines can act in eosinophil development and activation in vitro, but gene deletion or antibody blocking of IL-5 largely ablates eosinophilic responses in mod...
متن کامل